PT - JOURNAL ARTICLE AU - Rahadiani, Nur AU - Habiburrahman, Muhammad AU - Abdullah, Murdani AU - Jeo, Wifanto Saditya AU - Stephanie, Marini AU - Handjari, Diah Rini AU - Krisnuhoni, Ening TI - Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital AID - 10.1136/bmjopen-2022-060839 DP - 2022 Sep 01 TA - BMJ Open PG - e060839 VI - 12 IP - 9 4099 - http://bmjopen.bmj.com/content/12/9/e060839.short 4100 - http://bmjopen.bmj.com/content/12/9/e060839.full SO - BMJ Open2022 Sep 01; 12 AB - Objective To obtain annual incidence trends, understand clinicopathological characteristics, and forecast the future burden of colorectal cancer (CRC) in Indonesia.Design 11-year retrospective cross-sectional study.Setting A national referral hospital in Jakarta, Indonesia.Participants Data from 1584 eligible cases were recorded for trends and forecasting analyses; 433 samples were analysed to determine clinicopathological differences between young (<50 years) and old (≥50 years) patients.Methods Trend analyses were done using Joinpoint software, expressed in annual percentage change (APC), and a regression analysis was executed to generate a forecasting model. Patients’ characteristics were compared using χ2 or non-parametric tests.Main outcomes Analysis of trends, forecasting model, and clinicopathological features between the age groups.Results A significant increase in APC was observed among old patients (+2.38%) for CRC cases. Colon cancer increased remarkably (+9.24%) among young patients; rectal cancer trends were either stable or declining. The trend for right-sided CRC increased in the general population (+6.52%) and old patients (+6.57%), while the trend for left-sided CRC was stable. These cases are expected to be a significant health burden within the next 10 years. Patients had a mean age of 53.17±13.94, 38.1% were young, and the sex ratio was 1.21. Prominent characteristics were left-sided CRC, tumour size ≥5 cm, exophytic growth, adenocarcinoma, histologically low grade, pT3, pN0, inadequately dissected lymph nodes (LNs), LN ratio <0.05, no distant metastasis, early-stage cancer, no lymphovascular invasion, and no perineural invasion (PNI). Distinct features between young and old patients were found in the histological subtype, number of dissected LN, and PNI of the tumour.Conclusions Epidemiological trends and forecasting analyses of CRC cases in Indonesian patients showed an enormous increase in colon cancer in young patients, a particularly concerning trend. Additionally, young patients exhibited particular clinicopathological characteristics that contributed to disease severity.Data may be obtained from a third party and are not publicly available. All data relevant to the study are included in the article or uploaded as online supplemental information. Raw data was obtained from a third party and are not publicly available. All additional relevant data analyses to the study have been uploaded as online supplemental information. To obtain more details data, please contact our corresponding author.