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Evidence based practice
Protocol
Risk factors for new ischaemic cerebral lesions after carotid artery stenting: protocol for a systematic review and meta-analysis
  1. Yao Feng,
  2. Long Li,
  3. Xuesong Bai,
  4. Tao Wang,
  5. Yanfei Chen,
  6. Xiao Zhang,
  7. Feng Ling,
  8. Liqun Jiao
  1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
  1. Correspondence to Dr Liqun Jiao; liqunjiao{at}sina.cn

Abstract

Introduction New ischaemic cerebral lesions (NICL) detected by diffusion-weighted imaging MRI are common after carotid artery stenting (CAS), with an occurrence rate ranging from 18% to 57%. Many studies reported occurrence of NICL could increase risk of future cerebrovascular events and cognitive impairment. However, controversies about determinants for occurrence of NICL after CAS exist among studies, and one risk factor embodied in an article may not be in another. Aim of this study is to introduce a protocol for a systematic review and meta-analysis to identify risk factors associated with occurrence of NICL after CAS.

Methods and analysis All relevant literature referring to risk factors for occurrence of NICL after CAS will be searched on the major databases, such as PubMed, Embase, Web of Science and the Cochrane Library until 31 December 2018. Literature, which must be randomised controlled trials, case–control studies or cohort studies, will be included in accordance with the prespecified eligibility criteria. The risk of bias will be assessed using the Cochrane Collaboration criteria and the quality of evidence will be assessed with the corresponding scale. Data will be extracted with a form prepared before and analysed using RevMan V.5.3 analyses software. Heterogeneity will be assessed using I2 statistic. Our systematic review will be performed according to the guidance from the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.

Ethics and dissemination There is no need for ethical approval because primary data will not be attained. The systematic review will be presented at international conferences and published in peer-reviewed journals.

PROSPERO registration number CRD42019121129

  • carotid artery stenosis
  • carotid artery stenting
  • risk factors
  • DWI
  • meta-analysis

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi-org.ezproxy.u-pec.fr/10.1136/bmjopen-2019-030025

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    Footnotes

    • YF and LL contributed equally.

    • Contributors LJ and FL developed the initial idea for this study. YF, XB and XZ developed and revised the search strategy. TW, XZ and YC finished the study design. LJ, FL and YC were consulted about clinical issues. YF, WT and XB contributed to the original draft. YF and LL were responsible for the revision of the draft. YF and LL contributed equally to this article. All of the authors approved the final work prior to submission.

    • Funding statement This work was supported by the Ministry of Science and Technology of the People’s Republic of China (2016YFC1301700). The funder has no role in study design, data analysis and writing the manuscript.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.